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Contributors
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iii-iv
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Contents
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v-vii
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Forthcoming Issues
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viii
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Foreword
30 March 2012
This issue, edited by Drs Leahy and Cefalu, covers a very important aspect of diabetes care, namely, insulin therapy. As the reader will perceive, the topics chosen and authors contributing bring the ...
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Derek LeRoith
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ix-xi
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Preface
In 2002, the editors of this volume, Jack Leahy and Will Cefalu, edited a book entitled Insulin Therapy. It was made up of chapters from experts in the field regarding insulin physiology and therapy, ...
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Jack L. Leahy,
William T. Cefalu
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xiii-xiv
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Insulins: Past, Present, and Future
16 April 2012
This article highlights selected milestones in insulin discovery and its continued development as a pivotal therapy for diabetes. The last 90 years have witnessed tremendous progress in insulin therap...
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Carla A. Borgoño,
Bernard Zinman
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1-24
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Physiology of Glucose Homeostasis and Insulin Therapy in Type 1 and Type 2 Diabetes
26 April 2012
An input-output schematization of plasma glucose homeostasis provides quantitative information on glucose fluxes and their control by insulin. Insulin action is dependent on the target tissue, the rou...
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Ele Ferrannini
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25-39
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Reevaluating Goals of Insulin Therapy: Perspectives from Large Clinical Trials
09 April 2012
Recent large clinical trials have shown that intensive glycemic control can reduce microvascular complications, but appropriate and safe glycemic goals to improve macrovascular outcomes in patients wi...
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Matthew C. Riddle,
Kevin C.J. Yuen
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41-56
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Insulin Therapy and Hypoglycemia
19 April 2012
Hypoglycemia is the most important and common side effect of insulin therapy. It is also the rate limiting factor in safely achieving excellent glycemic control. A three-fold increased risk of severe ...
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Anthony L. McCall
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57-87
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Intensive Insulin Therapy in Patients with Type 1 Diabetes Mellitus
26 April 2012
There has been a significant increase in the prevalence of type 1 diabetes mellitus and type 2 diabetes mellitus in the past decade. The International Diabetes Foundation reported that there will be m...
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Sean M. Switzer,
Emily G. Moser,
Briana E. Rockler,
Satish K. Garg
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89-104
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Closed-Loop Insulin Delivery in Type 1 Diabetes
Advances in diabetes technology have led to significant improvements in the quality of life and care received by individuals with diabetes. Despite this, achieving tight glycemic control through inten...
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Hood Thabit,
Roman Hovorka
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105-117
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Insulin Therapy in Type 2 Diabetes Mellitus
Health care providers and patients have lots of choice to treat type 2 diabetes, but the blood glucose improvement is limited. The one therapy with unlimited potential (at least theoretically) is insu...
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Jack L. Leahy
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119-144
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Insulin Therapy in Children and Adolescents
27 February 2012
Insulin therapy is the mainstay of treatment in children and adolescents with type 1 diabetes (T1D) and is a key component in the treatment of type 2 diabetes (T2D) in this population as well. A major...
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William V. Tamborlane,
Kristin A. Sikes
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145-160
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Insulin Therapy in Pregnancy
06 January 2012
Insulin therapy is essential for optimal glycemic control during pregnancy in women with type 1 diabetes and is frequently required to optimize control in women with type 2 diabetes. Less commonly, wo...
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Aidan McElduff,
Robert G. Moses
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161-173
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Insulin Therapy for the Management of Hyperglycemia in Hospitalized Patients
20 February 2012
It has long been established that hyperglycemia with or without a prior diagnosis of diabetes increases both mortality and disease-specific morbidity in hospitalized patients and that goal-directed in...
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Marie E. McDonnell,
Guillermo E. Umpierrez
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175-201
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Index
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203-230
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