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December 2021

Claudio Marcocci, Filomena Cetani, Editors

Total serum calcium concentration has three components: (i) ionized serum calcium (about 50%), (ii) serum calcium complexed to anions (about 3%), and (iii) protein-bound (mostly albumin) serum calcium (about 47%). Hypercalcemia is defined as a serum calcium concentration greater than 2 standard deviations above the normal mean in a reference laboratory and is usually distinct according to serum calcium concentration in mild when below 12 mg/dL, moderate when between 12 and 14 mg/dL, and severe when greater than 14 mg/dL.

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Endocrinology and Metabolism Clinics of North America updates you on the latest trends in patient management, keeps you abreast of the newest advances, and provides a sound basis for choosing treatment options. Published quarterly—in March, June, September, and December—each issue features expert, state-of-the-art reviews on a single topic, including obesity, diabetes, thyroid disease, bone disorders, reproduction, hypertension, and much more.