Advertisement
Review Article| Volume 31, ISSUE 1, P173-189, March 2002

Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion

      Adequate nutrition is necessary for human growth and development. Obesity and malnutrition, two distinct disorders that occur when there is a mismatch between energy intake and energy consumption, can lead to serious disease [
      • Calle E
      • Thun M
      • Petrelli J
      • Rodriguez C
      • Heath Jr., C.W
      Body mass index and mortality in a prospective cohort of US adults.
      ,
      • Kopelman P
      Obesity as a medical problem.
      ]. There has been a shift in recent years in the epidemiology of diseases that affect nutrition. Although malnutrition is still present in the underdeveloped world, obesity, a condition associated with excessive energy intake, has become a major public health concern in the United States. It is estimated that 97.1 million adults (54.9% of the population) are overweight. Nearly one fourth of adults or 39.8 million individuals are also obese [
      • Mokdad A.H
      • Bowman B.A
      • Ford E.S
      • Vinicor F
      • Marks J
      • Koplan J.P
      The continuing epidemics of obesity and diabetes in the United States.
      ].
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Endocrinology and Metabolism Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Calle E
        • Thun M
        • Petrelli J
        • Rodriguez C
        • Heath Jr., C.W
        Body mass index and mortality in a prospective cohort of US adults.
        N Eng J Med. 1999; 15: 1097-1105
        • Kopelman P
        Obesity as a medical problem.
        Nature. 2000; 404: 635-643
        • Mokdad A.H
        • Bowman B.A
        • Ford E.S
        • Vinicor F
        • Marks J
        • Koplan J.P
        The continuing epidemics of obesity and diabetes in the United States.
        JAMA. 2001; 286: 1195-1200
        • Strata A
        • Ugolotti G
        • Contini C
        • Magnati G
        • Pugnoli C
        • Tirelli F
        • et al.
        Thyroid and obesity: survey of some function tests in a large obese population.
        Int J Obes. 1978; 2: 333-340
        • Turnbridge W.M.G
        • Evered D.C
        • Hall R
        • Appleton D
        • Brewis M
        • Clark F
        • et al.
        The spectrum of thyroid disease in a community. The Wickham survey.
        Clin Endocrinol. 1977; 7: 481-485
        • Zhang J
        • Lazar M
        The mechanism of action of thyroid hormones.
        Ann Rev Physiol. 2000; 62: 439-466
        • Vijayan E
        • McCann S.M
        Suppression of feeding and drinking activity in rats following intravascular injections of TRH.
        Endocrinology. 1977; 100: 1727-1730
        • Morley J.E
        • Levine A.S
        • Prasad C
        Histidyl proline diketopiperazine decreases food intake in rats.
        Brain Res. 1981; 210: 475-478
        • Silva J.E
        Thyroid hormone control of thermogenesis and energy balance.
        Thyroid. 1995; 5: 481-492
        • Al-Adsani H
        • Hoffer L
        • Silva J.E
        Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement.
        J Clin Endocrinol Metab. 1997; 82: 1118-1125
        • Chomard P
        • Vernhes G
        • Autissier N
        • Debry G
        Serum concentrations of total T4, T3, reverse and free T4, T3 in moderately obese patients.
        Hum Nutr Clin Nutr. 1985; 39: 371-378
        • Ford M
        • Cameron E
        • Ratcliffe W
        • Horn D.B
        • Toft A.D
        • Munro J.F
        TSH response to TRH in substantial obesity.
        Int J Obes. 1980; 4: 121-125
        • Duntas L
        • Haunter H
        • Rosenthal J
        • Pfeiffer E.F
        Thyrotopin releasing hormone immunoreactivity and thyroid function in obesity.
        Int J Obes. 1991; 15: 83-87
        • Amatruda J
        • Hochstein M
        • Hsu T
        • Lockwood D.H
        Hypothalamic and pituitary dysfunction in obese males.
        Int J Obes. 1982; 6: 183-189
        • Donders S
        • Pieters G
        • Heevel J
        • Ross H.A
        • Smals A.G
        • Kloppenborg P.W
        Disparity of TSH and prolactin responses to TSH releasing hormone in obesity.
        J Clin Endocrinol Metab. 1985; 61: 57-59
        • Glass A
        Endocrine aspects of obesity.
        Med Clin North Am. 1989; 73: 139-159
        • Danforth Jr., E
        • Horton E.S
        • O’Connell M
        • Sims E.A
        • Burger A.G
        • Ingbar S.W
        • et al.
        Dietary-induced alterations in thyroid hormone metabolism during overnutrition.
        J Clin Invest. 1979; 64: 1336-1347
        • LoPresti J
        • Gray D
        • Nicoloff J
        Influence of fasting and refeeding on 3,3′,5′- triiodothyronine metabolism in man.
        J Clin Endocrinol Metab. 1991; 72: 130-136
        • Pasquali R
        • Parenti M
        • Mattioli L
        • Capelli M
        • Cavazzini G
        • Baraldi G
        • et al.
        Effect of dietary carbohydrates during hypocaloric treatment of obesity on peripheral thyroid hormone metabolism.
        J Endocrinol Invest. 1982; 5: 47-52
        • Toubro S
        • Sorensen T
        • Ronn B
        • Christensen N.J
        • Astrup A
        Twenty-four–hour energy expenditure: the role of body composition, thyroid status, sympathetic activity, and family membership.
        J Clin Endocrinol Metab. 1996; 81: 2670-2674
        • Buscemi S
        • Verga S
        • Maneri R
        • Blunda G
        • Galluzzo A
        Influences of obesity and weight loss on thyroid hormones. A 3-3.5 year follow-up study on obese subjects with surgical bilio-pancreatic by-pass.
        J Endocrinol Invest. 1997; 5: 276-281
        • Moore R
        • Mehrishi J
        • Howard A
        • Mills I.H
        Lymphocyte thyroid hormone receptors in obesity.
        Int J Obes. 1982; 6: 541-548
        • Burman K
        • Latham K
        • Djuh Y
        • Smallridge R.C
        • Tseng Y.C
        • Lures Y.G
        • et al.
        Solubilized nuclear thyroid hormone receptors in circulating human mononuclear cells.
        J Clin Endocrinol Metab. 1980; 51: 106-116
        • Rosenbaum M
        • Hirsch J
        • Murphy E
        • Leibel R.L
        Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function.
        Am J Clin Nutr. 2000; 71: 1421-1432
        • Grant A
        • Edwards O
        • Howard A
        • Challand G.S
        • Wraight E.P
        • Mills I.H
        Thyroid hormone metabolism in obesity during semi-starvation.
        Clin Endocrinol. 1978; 3: 227-231
        • Lim C.F
        • Docter R
        • Krenning E.P
        • van Toor H
        • Bernard B
        • De Jong M
        • et al.
        Transport of thyroxine into cultured hepatocytes: effects of mild non-thyroidal illness and calorie restriction in obese subjects.
        Clin Endocrinol. 1994; 40: 79-85
        • Marine N
        • Hershman J
        • Maxwell M
        • Dornfeld L.P
        • Schroth P
        Dietary restriction on serum thyroid hormone levels.
        Am J Med Sci. 1991; 301: 310-313
        • Byerley L
        • Hebe D
        Metabolic effects of triiodothyronine replacement during fasting in obese subjects.
        J Clin Endocrinol Metab. 1996; 81: 968-976
        • Beard J
        • Borel M
        • Peterson F
        Changes in iron status during weight loss with very-low-energy diets.
        Am J Clin Nutr. 1997; 66: 104-110
        • Drent M
        • Popp-Snijders C
        • Ader H
        • Jansen J.B
        • van der Veen E.A
        Lipase inhibition and hormonal status, body composition and gastrointestinal processing of a liquid high-fat mixed meal in moderately obese subjects.
        Obes Res. 1995; 3: 573-581
        • Tamai H
        • Mori K
        • Matsubayashi S
        • Kiyohara K
        • Nakagawat T
        • Okimura M.C
        • et al.
        Hypothalamic-pituitary-thyroidal dysfunctions in anorexia nervosa.
        Psychother Psychosom. 1986; 46: 127-131
        • Croxson M
        • Ibbertson H
        Low serum triiodothyronine (T3) and hypothyroidism in anorexia nervosa.
        J Clin Endocrinol Metab. 1977; 44: 167-174
        • Camanni F
        • Ghigo E
        Relationships between IGF-1 and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients.
        Int J Obes Relat Metab Disord. 1999; 23: 612-618
        • Hartman M.L
        Physiological regulators of growth hormone secretion.
        in: L JJO A.J Growth hormone in adults. Cambridge University Press, Cambridge1996
        • Veldhuis J
        • Iranmanesh A
        • Ho K
        • Waters M.J
        • Johnson M.L
        • Lizarralde G
        Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man.
        J Clin Endocrinol Metab. 1991; 72: 51-59
        • Williams T
        • Berelowitz M
        • Joffe S
        • Thorner M
        • Rivier J
        • Vale W
        • et al.
        Impaired growth hormone responses to growth hormone-releasing factor in obesity: a pituitary defect reversed with weight reduction.
        N Engl J Med. 1984; 311: 1403-1407
        • Pijl H
        • Langendonk J
        • Burggraaf J
        • Frölich M
        • Cohen A.F
        • Veldhuis J.D
        Altered neuroregulation of GH secretion in viscerally obese premenopausal women.
        J Clin Endocrinol Metab. 2001; 86: 5509-5515
        • Johannsson G
        • Marin P
        • Lonn L
        • Ottosson M
        • Stenlof K
        • Bjorntorp P
        • et al.
        Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure.
        J Clin Endocrinol Metab. 1997; 82: 727-734
        • Kelijman M
        • Frohman L
        Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary manipulation in obese and non-obese subjects.
        J Clin Endocrinol Metab. 1988; 66: 489-494
        • Kanaley J.A
        • Weatherup-Dentes M.M
        • Jaynes E.B
        • Hartman M.L
        Obesity attenuates the growth hormone response to exercise.
        J Clin Endocrinol Metab. 1999; 84: 3156-3161
        • Rasmussen M.H
        • Hvidberg A, Juul A
        • Main K.M
        • Gotfredsen A
        • Skakkebaek N.E
        • et al.
        Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects.
        J Clin Endocrinol Metab. 1995; 80: 1407-1415
        • Felsing N.E
        • Brasel J.A
        • Cooper D.M
        Effect of low and high intensity exercise on circulating growth hormone in men.
        J Clin Endocrinol Metab. 1992; 75: 157-162
        • Karagiorgos A
        • Garcia J.F
        • Brooks G.A
        Growth hormone response to continuous and intermittent exercise.
        Med Sci Sports. 1979; 11: 302-307
        • Crockford P
        • Salmon P
        Hormones and obesity: changes in insulin and growth hormone secretion following surgically induced weight loss.
        Can Med Assoc J. 1970; 103: 147-150
        • Gianotti L
        • Arvat E
        • Valetto M.R
        • Ramunni J
        • Divito L
        • Maccagno B
        • et al.
        Effects of beta-adrenergic agonists and antagonists on the growth hormone response to growth hormone releasing hormone in anorexia nervosa.
        Biol Psych. 1998; 43: 181-187
        • Jenrenaud B
        • Halimi S
        • Vandewerve G
        Neuroendocrine disorders seen as triggers of the triad: obesity—insulin resistance-abnormal glucose tolerance.
        Diabetes Metab Rev. 1985; 1: 261-285
        • Guillaume-Gentil C
        • Rohner-Jenrenaud F
        • Abramo F
        • Bestetti G.E
        • Rossi G.L
        • Jenrenaud B
        Abnormal regulation of the hypothalamus-pituitary-adrenal axis in the genetically obese fa/fa rat.
        Endocrinology. 1990; 126: 1873-1879
        • Schteingart D.E
        • Gregerman R.I
        • Conn J.W
        A comparison of the characteristics of increased adrenocortical function in obesity and Cushing’s syndrome.
        Metabolism. 1963; 12: 484-497
        • Marin P
        • Darin N
        • Amemiya T
        • Andersson B
        • Jern S
        • Bjorntorp P
        Cortisol secretion in relation to body fat distribution in premenopausal women.
        Metab Clin Exp. 1992; 41: 882-886
        • Pasquali R
        • Contobelli S
        • Casimirri F
        • Capelli M
        • Bortoluzzi L
        • Flamia R
        • et al.
        The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution.
        J Clin Endocrinol Metab. 1993; 77: 341-346
        • Cohen M.R
        • Pickar D
        • Cohen R.M
        Plasma cortisol and beta-endorphin immunoreactivity in human obesity.
        Psychosom Med. 1984; 46: 454-462
        • Starkman M.N
        • Schteingart D.E
        • Schork M.A
        Depressed mood and psychiatric manifestations of Cushing’s syndrome: relationship to hormone levels.
        Psychosom Med. 1981; 43: 3-18
        • Margules D.L
        • Moisset B
        • Lewis M.I
        • Shibuya H
        • Pert C.B
        BE is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa).
        Science. 1978; 202: 988-991
        • Bernasconi S
        • Petraglia F
        • Iughetti L
        • Marcelcini C
        • Lamborghini A
        • Facchinetti F
        • et al.
        Impaired BE response to human corticotropin releasing hormone in obese children.
        ACTA Endocrinol. 1988; 119: 7-10
        • Facchinetti F
        • Liverieri C
        • Petraglia F
        • Cortona L
        • Severi F
        • Genazzani A.R
        Dexamethasone failed to suppress hyperendorphinemia of obese children.
        ACTA Endocrinol. 1987; 116: 90-94
        • Giugliano D
        • Cozzolino D
        • Torella R
        • Lefebvre P.J
        • Franchimont P
        • D'onofrio F
        Persistence of altered metabolic responses to BE after normalization of body weight in human obesity.
        Acta Endocrinol (Copenh). 1991; 124: 159-165
        • Cooper S.J
        Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat.
        Neuropharmacology. 1983; 22: 323-328
        • Maggio C.A
        • Presta E
        • Bracco E.F
        • Vasseli J.R
        • Kissilaff H.R
        • Phohl D.N
        • et al.
        Naltrexone and human eating behavior: a dose-ranging in-patient trial in moderately obese men.
        Brain Res Bull. 1985; 14: 657-661
        • Bjorntorp P
        Abdominal obesity and the development of non-insulin-dependent diabetes mellitus.
        Diabetes Metab Rev. 1988; 4: 615-622
        • Haffner S.M
        Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation.
        Int J Obes Relat Metab Disord. 2000; 24: S56-S58
        • Ljung T
        • Holm G
        • Friberg P
        • Andersson B
        • Bengtsson B.A
        • Svenson J
        • et al.
        The activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in relation to waist/hip circumference ratio in men.
        Obes Res. 2000; 8: 487-495
        • Golub M.S
        The adrenal and the metabolic syndrome.
        Curr Hypertens Rep. 2001; 3: 117-120
        • Yanovski J.A
        • Cutler Jr., G.B
        • Chrousos G.P
        • Nieman L.K
        Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing’s syndrome from pseudo-Cushing’s states.
        JAMA. 1993; 2269: 2232-2238
        • Chrousos G.P
        The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes.
        Int J Obes Relat Disord. 2000; 24: S50-S55
        • Bjorntorp P
        • Rosmond R
        The metabolic syndrome—a neuroendocrine disorder?.
        Br J Nutr. 2000; 83: S49-S57
        • Lupien S.J
        • deLeon M
        • deSanti S
        • Convit A
        • Tarshish C
        • Nair N.P
        • et al.
        Cortisol levels during human aging predict hippocampal atrophy and memory deficits.
        Nat Neurosci. 1998; 1: 69-73
        • Starkman M.N
        • Gebarski S.S
        • Berent S
        • Schteingart D.E
        Hippocampal formation volume, memory dysfunction and cortisol levels in patients with Cushing’s syndrome.
        Biol Psych. 1992; 32: 756-765
        • Steffens D.C
        • Byrum C.E
        • McQuiod D.R
        • Greenberg D.L
        • Paync M.E
        • Blitchington T.F
        • et al.
        Hippocampal volume in geriatric depression.
        Biol Psych. 2000; 48: 301-309
        • Leal A.M
        • Moreira A.C
        Food and the circadian activity of the hypothalamic-pituitary-adrenal axis.
        Braz J Med Biol Res. 1997; 30: 1391-1405
        • Cavaghini F
        • Croci M
        • Putignano P
        • Petroni M.L
        • Invitti C
        Glucocorticoids and neuro-endocrine function.
        Int J Obes Relat Metab Disord. 2000; 24: S77-S79
        • Yanovski J.A
        • Yanovski S.Z
        • Gold P.W
        • Chrousos G.P
        Differences in corticotropin-releasing hormone-stimulated adrenocorticotropin and cortisol before and after weight loss.
        J Clin Endocrinol Metab. 1997; 82: 1874-1878
        • Jung R.T
        • Shetty P.S
        • James W.P
        • Barrand M.A
        • Callingham B.A
        Plasma catecholamines and autonomic responsiveness in obesity.
        Int J Obes. 1982; 6: 131-141
        • Sowers J.R
        • Nyby M
        • Stern N
        • Beck F
        • Baron S
        • Catania R
        • et al.
        Blood pressure and hormone changes associated with weight reduction in the obese.
        Hypertension. 1982; 4: 868-891
        • Astrup A
        • Andersen T
        • Christensen N.J
        • Bulow J
        • Madsen J
        • Breum L
        • et al.
        Impaired glucose-induced thermogenesis and arterial norepinephrine response persist after weight reduction in obese humans.
        Am J Clin Nutr. 1990; 51: 331-337
        • Licinio J
        • Wong M.L
        • Gold P.W
        The hypothalamic-pituitary-adrenal axis in anorexia nervosa.
        Psych Res. 1996; 62: 75-83
        • Duclos M
        • Corcuff J.B
        • Roger P
        • Tabarin A
        The dexamethasone-suppressed corticotrophin-releasing hormone stimulation test in anorexia nervosa.
        Clin Endocrinol. 1999; 51: 725-731