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Type 2 Diabetes in Pregnancy

  • Anil Kapur
    Correspondence
    Corresponding author.
    Affiliations
    World Diabetes Foundation, 30 A, Krogshoejvej, Bagsverd 2880, Denmark

    FIGO Pregnancy and NCD Committee, Jabotinski Street, Petah Tiqwa 49100, Israel
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  • Harold David McIntyre
    Affiliations
    FIGO Pregnancy and NCD Committee, Jabotinski Street, Petah Tiqwa 49100, Israel

    UQ Mater Clinical Unit, Faculty of Medicine, Mater Health Services, University of Queensland, Raymond Terrace, South Brisbane, Brisbane, Qld 4101, Australia
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  • Moshe Hod
    Affiliations
    FIGO Pregnancy and NCD Committee, Jabotinski Street, Petah Tiqwa 49100, Israel

    Department of Obstetrics and Gynecology, Clalit Health Services, Mor Women's Health Center, Rabin Medical Center, Tel Aviv University, 18 Aba Ahimeir St., Tel Aviv 6949204, Israel
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      References

      1. International diabetes federation IDF diabetes atlas 7th Edition.
        (Available at:) (Accessed October 15, 2018)
        • World Health Organization
        Obesity and overweight fact sheet Updated June 2016.
        (Available at:) (Accessed October 15, 2018)
        • Albrecht S.S.
        • Kuklina E.V.
        • Bansil P.
        • et al.
        Diabetes trends among delivery hospitalizations in the U.S., 1994-2004.
        Diabetes Care. 2010; 33: 768-773
        • Bardenheier B.H.
        • Imperatore G.
        • Devlin H.M.
        • et al.
        Trends in pre-pregnancy diabetes among deliveries in 19 U.S. states, 2000-2010.
        Am J Prev Med. 2015; 48: 154-161
        • Mackin S.T.
        • Nelson S.M.
        • Kerssens J.J.
        • et al.
        SDRN epidemiology group diabetes and pregnancy: national trends over a 15 year period.
        Diabetologia. 2018; 61: 1081-1088
        • Bell R.
        • Bailey K.
        • Cresswell T.
        • et al.
        Trends in prevalence and outcomes of pregnancy in women with pre-existing type I and type II diabetes.
        BJOG. 2008; 115: 445-452
        • Fadl H.E.
        • Simmons D.
        Trends in diabetes in pregnancy in Sweden 1998-2012.
        BMJ Open Diabetes Res Care. 2016; 4: e000221
        • Metcalfe A.
        • Sabr Y.
        • Hutcheon J.A.
        • et al.
        Trends in obstetric intervention and pregnancy outcomes of canadian women with diabetes in pregnancy from 2004 to 2015.
        J Endocr Soc. 2017; 1: 1540-1549
        • Zhou Q.
        • Wang Q.
        • Shen H.
        • et al.
        Prevalence of diabetes and regional differences in Chinese women planning pregnancy: a nationwide population-based cross-sectional study.
        Diabetes Care. 2017; 40: e16-e18
        • Kragelund Nielsen K.
        • Damm P.
        • Kapur A.
        • et al.
        Risk factors for hyperglycaemia in pregnancy in Tamil Nadu, India.
        PLoS One. 2016; 11: e0151311
        • World Health Organization
        Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy.
        WHO/NMH/MND/13.2, 2013 (Available at) (Accessed October 15, 2018)
        • Shields B.M.
        • Hicks S.
        • Shepherd M.H.
        • et al.
        Maturity-onset diabetes of the young (MODY): how many cases are we missing?.
        Diabetologia. 2010; 53: 2504-2508
        • Kropff J.
        • Selwood M.P.
        • McCarthy M.I.
        • et al.
        Prevalence of monogenic diabetes in young adults: a community-based, cross-sectional study in Oxfordshire, UK.
        Diabetologia. 2011; 54: 1261-1263
        • Pihoker C.
        • Gilliam L.K.
        • Ellard S.
        • et al.
        Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth.
        J Clin Endocrinol Metab. 2013; 98: 4055-4062
      2. OMIM - Online Mendelian Inheritance in man.
        (Available at:)
        • Ellard S.
        • Beards F.
        • Allen L.
        • et al.
        A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.
        Diabetologia. 2000; 43: 250-253
        • Doddabelavangala M.M.
        • Chapla A.
        • Hesarghatta Shyamasunder A.
        • et al.
        Comprehensive maturity onset diabetes of the young (MODY) gene screening in pregnant women with diabetes in India.
        PLoS One. 2017; 12: e0168656
        • Angueira A.R.
        • Ludvik A.E.
        • Reddy T.E.
        • et al.
        New insights into gestational glucose metabolism: lessons learned from 21st century approaches.
        Diabetes. 2015; 64: 327-334
        • Dekel N.
        • Gnainsky Y.
        • Granot I.
        • et al.
        Inflammation and implantation.
        Am J Reprod Immunol. 2010; 63: 17-21
        • Mor G.
        • Cardenas I.
        The immune system in pregnancy: a unique complexity.
        Am J Reprod Immunol. 2010; 63: 425-433
        • Romero R.
        • Espinoza J.
        • Goncalves L.F.
        • et al.
        Inflammation in preterm and term labor and delivery.
        Semin Fetal Neonatal Med. 2006; 11: 317-326
        • Newbern D.
        • Freemark M.
        Placental hormones and the control of maternal metabolism and fetal growth.
        Curr Opin Endocrinol Diabetes Obes. 2011; 18: 409-416
        • Butler A.E.
        • Cao-Minh L.
        • Galasso R.
        • et al.
        Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy.
        Diabetologia. 2010; 53: 2167-2176
        • Jacovetti C.
        • Abderrahmani A.
        • Parnaud G.
        • et al.
        MicroRNAs contribute to compensatory B cell expansion during pregnancy and obesity.
        J Clin Invest. 2012; 122: 3541-3551
        • Catalano P.M.
        Trying to understand gestational diabetes.
        Diabet Med. 2014; 31: 273-281
        • Wang M.
        • Xia W.
        • Li H.
        • et al.
        Normal pregnancy induced glucose metabolic stress in a longitudinal cohort of healthy women: novel insights generated from a urine metabolomics study.
        Medicine (Baltimore). 2018; 97: e12417
        • Baeyens L.
        • Hindi S.
        • Sorenson R.L.
        • et al.
        Beta-cell adaptation in pregnancy.
        Diabetes Obes Metab. 2016; 18: 63-70
        • Nelson S.M.
        • Matthews P.
        • Poston L.
        Maternal metabolism and obesity: modifiable determinants of pregnancy outcome.
        Hum Reprod Update. 2010; 16: 255-275
        • Desoye G.
        • Nolan C.J.
        The fetal glucose steal: an underappreciated phenomenon in diabetic pregnancy.
        Diabetologia. 2016; 59: 1089-1094
        • Metzger B.E.
        • Lowe L.P.
        • Dyer A.R.
        • et al.
        Hyperglycemia and adverse pregnancy outcomes.
        N Engl J Med. 2008; 358: 1991-2002
        • Freinkel N.
        Banting lecture 1980. Of pregnancy and progeny.
        Diabetes. 1980; 29: 1023-1035
        • Carpenter M.W.
        • Canick J.A.
        • Hogan J.W.
        • et al.
        Amniotic fluid insulin at 14-20 weeks gestation: association with later maternal glucose intolerance and birth macrosomia.
        Diabetes care. 2001; 24: 1259-1263
        • Schwartz R.
        • Gruppuso P.A.
        • Petzold K.
        • et al.
        Hyperinsulinemia and macrosomia in the fetus of the diabetic mother.
        Diabetes Care. 1994; 17: 640-648
        • Starikov R.
        • Inman K.
        • Chen K.
        • et al.
        Comparison of placental findings in type 1 and type 2 diabetic pregnancies.
        Placenta. 2014; 35: 1001-1006
        • Gabbay-Benziv R.
        • Baschat A.A.
        Gestational diabetes as one of the “great obstetrical syndromes”—the maternal, placental, and fetal dialog.
        Best Pract Res Clin Obstet Gynaecol. 2015; 29: 150-155
        • Balsells M.
        • García-Patterson A.
        • Gich I.
        • et al.
        Maternal and fetal outcome in women with type 2 versus type 1 diabetes mellitus: a systematic review and metaanalysis.
        J Clin Endocrinol Metab. 2009; 94: 4284-4291
        • Billionnet C.
        • Mitanchez D.
        • Weill A.
        • et al.
        Gestational diabetes and adverse perinatal outcomes from 716,152 births in France in 2012.
        Diabetologia. 2017; 60: 636-644
        • Wahabi H.
        • Fayed A.
        • Esmaeil S.
        • et al.
        Prevalence and complications of pregestational and gestational diabetes in Saudi women: analysis from Riyadh mother and baby cohort study (RAHMA).
        Biomed Res Int. 2017; 2017: 6878263
        • Nielsen G.L.
        • Nogard B.
        • Puho E.
        • et al.
        Risk of specific congenital abnormalities in offspring of women with diabetes.
        Diabet Med. 2005; 22: 693-696
        • Dart A.B.
        • Ruth C.A.
        • Sellers E.A.
        • et al.
        Maternal diabetes mellitus and congenital anomalies of the kidney and urinary tract (CAKUT) in the child.
        Am J Kidney Dis. 2015; 65: 684-691
        • Liu S.
        • Rouleau J.
        • León J.A.
        • Canadian Perinatal Surveillance System
        • et al.
        Impact of pre-pregnancy diabetes mellitus on congenital anomalies, Canada, 2002-2012.
        Health Promot Chronic Dis Prev Can. 2015; 35: 79-84
        • Jovanovič L.
        • Liang Y.
        • Weng W.
        • et al.
        Trends in the incidence of diabetes, its clinical sequelae, and associated costs in pregnancy.
        Diabetes Metab Res Rev. 2015; 31: 707-716
        • Serehi A.A.
        • Ahmed A.M.
        • Shakeel F.
        • et al.
        A comparison on the prevalence and outcomes of gestational versus type 2 diabetes mellitus in 1718 Saudi pregnancies.
        Int J Clin Exp Med. 2015; 8: 11502-11507
        • Klingensmith G.J.
        • Pyle L.
        • Nadeau K.J.
        • TODAY Study Group
        • et al.
        Pregnancy outcomes in youth with type 2 diabetes: the TODAY study experience.
        Diabetes Care. 2016; 39: 122-129
        • Wicklow B.A.
        • Sellers E.A.C.
        • Sharma A.K.
        • et al.
        Association of gestational diabetes and type 2 diabetes exposure in utero with the development of type 2 diabetes in first nations and non-first nations offspring.
        JAMA Pediatr. 2018; 172: 724-731
        • Clausen T.D.
        • Mathiesen E.R.
        • Hansen T.
        • et al.
        High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia.
        Diabetes Care. 2008; 31: 340-346
        • Dabelea D.
        • Mayer-Davis E.J.
        • Lamichhane A.P.
        • et al.
        Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study.
        Diabetes Care. 2008; 31: 1422-1426
        • Pettitt D.J.
        • Lawrence J.M.
        • Beyer J.
        • et al.
        Association between maternal diabetes in utero and age at offspring's diagnosis of type 2 diabetes.
        Diabetes Care. 2008; 31: 2126-2130
        • Ornoy A.
        Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes.
        Pediatr Endocrinol Rev. 2005; 3: 104-113
        • Xiang A.H.
        • Wang X.
        • Martinez M.P.
        • et al.
        Maternal gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes during pregnancy and risk of ADHD in offspring.
        Diabetes Care. 2018; https://doi.org/10.2337/dc18-0733
        • Li M.
        • Fallin M.D.
        • Riley A.
        • et al.
        The association of maternal obesity and diabetes with autism and other developmental disabilities.
        Pediatrics. 2016; 137: e20152206
        • Xu G.
        • Jing J.
        • Bowers K.
        • et al.
        Maternal diabetes and the risk of autism spectrum disorders in the offspring: a systematic review and meta-analysis.
        J Autism Dev Disord. 2014; 44: 766-775
        • Rasmussen K.L.
        • Laugesen C.S.
        • Ringholm L.
        • et al.
        Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes.
        Diabetologia. 2010; 53: 1076-1083
        • Egan A.M.
        • McVicker L.
        • Heerey A.
        • et al.
        Diabetic retinopathy in pregnancy: a population-based study of women with pre-gestational diabetes.
        J Diabetes Res. 2015; 2015: 310239
        • Makwana T.
        • Takkar B.
        • Venkatesh P.
        • et al.
        Prevalence, progression, and outcomes of diabetic retinopathy during pregnancy in Indian scenario.
        Indian J Ophthalmol. 2018; 66: 541-546
        • Kitzmiller J.L.
        • Block J.M.
        • Brown F.M.
        • et al.
        Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care.
        Diabetes Care. 2008; 31: 1060-1079
        • Eppens M.C.
        • Craig M.E.
        • Jones T.W.
        • et al.
        International Diabetes Federation Western Pacific Region Steering Committee. Type 2 diabetes in youth from the Western Pacific region: glycaemic control, diabetes care and complications.
        Curr Med Res Opin. 2006; 22: 1013-1020
        • Damm J.A.
        • Asbjörnsdóttir B.
        • Callesen N.F.
        • et al.
        Diabetic nephropathy and microalbuminuria in pregnant women with type 1 and type 2 diabetes: prevalence, antihypertensive strategy, and pregnancy outcome.
        Diabetes Care. 2013; 36: 3489-3494
        • Dart A.B.
        • Sellers E.A.
        • Martens P.J.
        • et al.
        High burden of kidney disease in youth-onset type 2 diabetes.
        Diabetes Care. 2012; 35: 1265-1271
        • Bramham K.
        Diabetic nephropathy and pregnancy.
        Semin Nephrol. 2017; 37: 362-369
        • Ringholm L.
        • Damm J.A.
        • Vestgaard M.
        • et al.
        Diabetic nephropathy in women with preexisting diabetes: from pregnancy planning to breastfeeding.
        Curr Diab Rep. 2016; 16: 12
        • Hod M.
        • Kapur A.
        • Sacks D.A.
        • et al.
        The International Federation of Gynecology and Obstetrics (FIGO) Initiative on gestational diabetes mellitus: a pragmatic guide for diagnosis, management, and care.
        Int J Gynaecol Obstet. 2015; 131: S173-S211
        • Cea-Soriano L.
        • García-Rodríguez L.A.
        • Brodovicz K.G.
        • et al.
        Real world management of pregestational diabetes not achieving glycemic control for many patients in the UK.
        Pharmacoepidemiol Drug Saf. 2018; 27: 940-948
        • Sina M.
        • MacMillan F.
        • Dune T.
        • et al.
        Development of an integrated, district-wide approach to pre-pregnancy management for women with pre-existing diabetes in a multi-ethnic population.
        BMC Pregnancy Childbirth. 2018; 18: 402
        • Klein J.
        • Boyle J.A.
        • Kirkham R.
        • et al.
        Preconception care for women with type 2 diabetes mellitus: a mixed-methods study of provider knowledge and practice.
        Diabetes Res Clin Pract. 2017; 129: 105-115
        • Murphy H.R.
        • Bell R.
        • Dornhorst A.
        • et al.
        Pregnancy in diabetes: challenges and opportunities for improving pregnancy outcomes.
        Diabet Med. 2018; 35: 292-299
        • Yamamoto J.M.
        • Hughes D.J.F.
        • Evans M.L.
        • et al.
        Community-based pre-pregnancy care programme improves pregnancy preparation in women with pregestational diabetes.
        Diabetologia. 2018; https://doi.org/10.1007/s00125-018-4613-3
        • Owens L.A.
        • Egan A.M.
        • Carmody L.
        • et al.
        Ten years of optimizing outcomes for women with type 1 and type 2 diabetes in pregnancy - the Atlantic DIP experience.
        J Clin Endocrinol Metab. 2016; 101: 1598-1605
        • Egan A.M.
        • Danyliv A.
        • Carmody L.
        • et al.
        A pre pregnancy care program for women with diabetes: effective and cost saving.
        J Clin Endocrinol Metab. 2016; 101: 1807-1815
        • Peterson C.
        • Grosse S.D.
        • Li R.
        • et al.
        Preventable health and cost burden of adverse birth outcomes associated with pregestational diabetes in the United States.
        Am J Obstet Gynecol. 2015; 212: 74.e1-9
        • American Diabetes Association
        Management of diabetes in pregnancy: standards of medical care in diabetes-2018.
        Diabetes Care. 2018; 41: S137-S143
        • Gourdy P.
        Diabetes and oral contraception.
        Best Pract Res Clin Endocrinol Metab. 2013; 27: 67-76https://doi.org/10.1016/j.beem.2012.11.001
        • Parks C.
        • Peipert J.F.
        Eliminating health disparities in unintended pregnancy with long-acting reversible contraception (LARC).
        Am J Obstet Gynecol. 2016; 214: 681-688
        • Jovanovic L.G.
        Using meal-based self-monitoring of blood glucose as a tool to improve outcomes in pregnancy complicated by diabetes.
        Endocr Pract. 2008; 14: 239-247
        • Moy F.M.
        • Ray A.
        • Buckley B.S.
        • et al.
        Techniques of monitoring blood glucose during pregnancy for women with pre-existing diabetes.
        Cochrane Database Syst Rev. 2017; (CD009613)
        • Murphy H.R.
        • Rayman G.
        • Lewis K.
        • et al.
        Effectiveness of continuous glucose monitoring in pregnant women with diabetes: randomised clinical trial.
        BMJ. 2008; 337: a1680
        • Secher A.L.
        • Ringholm L.
        • Andersen H.U.
        • et al.
        The effect of real-time continuous glucose monitoring in pregnant women with diabetes: a randomized controlled trial.
        Diabetes care. 2013; 36: 1877-1883
        • Voormolen D.N.
        • DeVries J.H.
        • Sanson R.M.E.
        • et al.
        Continuous glucose monitoring during diabetic pregnancy (GlucoMOMS): a multicentre randomized controlled trial.
        Diabetes Obes Metab. 2018; 20: 1894-1902
        • Feig D.S.
        • Donovan L.E.
        • Corcoy R.
        • CONCEPTT Collaborative Group
        • et al.
        Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicenter international randomised controlled trial.
        Lancet. 2017; 390 ([Erratum in: Lancet 2017;390(10110):2346]): 2347-2359
        • deVeciana M.
        • Major C.A.
        • Morgan M.A.
        Postprandial versus preprandial blood glucose monitoring in women with gestational diabetes mellitus requiring insulin therapy.
        N Engl J Med. 1995; 333: 1237-1241
        • Combs C.A.
        • Gunderson E.
        • Kitsmiller J.L.
        Relationship of fetal macrosomia to maternal postprandial glucose control during pregnancy.
        Diabetes Care. 1992; 15: 1251-1257
        • Jovanovic L.
        • Peterson C.M.
        • Reed G.F.
        Maternal postprandial glucose levels and infant birth weight: the Diabetes in Early Pregnancy study.
        Am J Obstet Gynecol. 1991; 164: 103-111
        • Andersen O.
        • Hertel J.
        • Schmølker L.
        • et al.
        Influence of the maternal plasma glucose concentration at delivery on the risk of hypoglycaemia in infants of insulin-dependent diabetic mothers.
        Acta Paediatr Scand. 1985; 74: 268-273
        • Curet L.B.
        • Izquierdo L.A.
        • Gilson G.J.
        • et al.
        Relative effects of antepartum and intrapartum maternal blood glucose levels on incidence of neonatal hypoglycemia.
        J Perinatol. 1997; 17: 113-115
        • Mimouni F.
        • Miodovnik M.
        • Siddiqi T.A.
        • et al.
        Perinatal asphyxia in infants of insulin-dependent diabetic mothers.
        J Pediatr. 1988; 113: 345-353
        • Magee L.A.
        • von Dadelszen P.
        • Rey E.
        • et al.
        Less-tight versus tight control of hypertension in pregnancy.
        N Engl J Med. 2015; 372: 407-417
        • American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy
        Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy.
        Obstet Gynecol. 2013; 122: 1122-1131
        • Institute of Medicine
        Weight gain during pregnancy: reexamining the guidelines.
        National Academies Press (US), Washington, DC2009
        • Artal R.
        • Catanzaro R.B.
        • Gavard J.A.
        • et al.
        A lifestyle intervention of weight-gain restriction: diet and exercise in obese women with gestational diabetes mellitus.
        Appl Physiol Nutr Metab. 2007; 32: 596-601
        • Catalano P.M.
        • Mele L.
        • Landon M.B.
        • et al.
        Inadequate weight gain in overweight and obese pregnant women: what is the effect on fetal growth?.
        Am J Obstet Gynecol. 2014; 211 (137.e1–7)
        • Committee on Practice Bulletins–Obstetrics
        Practice Bulletin No. 137: Gestational diabetes mellitus.
        Obstet Gynecol. 2013; 122: 406-416
        • Yogev Y.
        • Ben-Haroush A.
        • Chen R.
        • et al.
        Active induction management of labor for diabetic pregnancies at term; mode of delivery and fetal outcome–a single center experience.
        Eur J Obstet Gynecol Reprod Biol. 2004; 114: 166-170
        • Caughey A.B.
        • Cahill A.G.
        • Guise J.M.
        • et al.
        • American College of Obstetricians and Gynecologists (College); Society for Maternal-Fetal Medicine
        Safe prevention of the primary cesarean delivery.
        Am J Obstet Gynecol. 2014; 210: 179-193
      3. American Dietetic Association, Medical Nutrition Therapy Evidence Based Guide for Practice: Nutrition Practice Guidelines for Gestational Diabetes [CD.ROM]. American Dietetic Association, Chicago (IL)2001
        • Franz M.J.
        • Monk A.
        • Barry B.
        • et al.
        Effectiveness of medical nutrition therapy provided by dietitians in the management of non-insulin-dependent diabetes mellitus: a randomized, controlled clinical trial.
        J Am Diet Assoc. 1995; 95: 1009-1017
        • American Diabetes Association
        Gestational diabetes mellitus.
        Diabetes Care. 2004; 27: S88-S90
        • Snyder J.
        • Gray-Donald K.
        • Koski K.G.
        Predictors of infant birth weight in gestational diabetes.
        Am J Clin Nutr. 1994; 59: 1409-1414
        • Institute of Medicine
        Dietary reference intakes: energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids.
        National Academies Press, Washington, DC2002
        • Viana L.V.
        • Gross J.L.
        • Azevedo M.J.
        Dietary intervention in patients with gestational diabetes mellitus: a systematic review and meta-analysis of randomized clinical trials on maternal and newborn outcomes.
        Diabetes Care. 2014; 37: 3345-3355
        • Ekpebegh C.O.
        • Coetzee E.J.
        • van derMerwe L.
        • et al.
        A 10-year retrospective analysis of pregnancy outcome in pregestational type 2 diabetes: comparison of insulin and oral glucose-lowering agents.
        Diabet Med. 2007; 24: 253-258
        • Brunerova L.
        • Rahelić D.
        • Ceriello A.
        • et al.
        Use of oral antidiabetic drugs in the treatment of maturity-onset diabetes of the young: a mini review.
        Diabetes Metab Res Rev. 2018; 34https://doi.org/10.1002/dmrr.2940
        • Hickman M.A.
        • McBride R.
        • Boggess K.A.
        • et al.
        Metformin compared with insulin in the treatment of pregnant women with overt diabetes: a randomized controlled trial.
        Am J Perinatol. 2013; 30: 483-490
        • Ainuddin J.A.
        • Karim N.
        • Zaheer S.
        • et al.
        Metformin treatment in type 2 diabetes in pregnancy: an active controlled, parallel-group, randomized, open label study in patients with type 2 diabetes in pregnancy.
        J Diabetes Res. 2015; 2015: 325851
        • Gilbert C.
        • Valois M.
        • Koren G.
        Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis.
        Fertil Steril. 2006; 86: 658-663
        • Feig D.S.
        • Murphy K.
        • Asztalos E.
        • on behalf of the MiTy Collabortive Group
        • et al.
        Metformin in women with type 2 diabetes in pregnancy (MiTy): a multi-center randomized controlled trial.
        BMC Pregnancy Childbirth. 2016; 16: 173
        • Henderson J.T.
        • Whitlock E.P.
        • O'Connor E.
        • et al.
        Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S Preventive Services Task Force.
        Annals of Internal Medicine. 2014; 160: 695-703
        • Rolnik D.L.
        • Wright D.
        • Poon L.C.
        • et al.
        Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia.
        N Engl J Med. 2017; 377: 613-622
        • Horta B.L.
        • Loret de Mola C.
        • Victora C.G.
        Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis.
        Acta Paediatr. 2015; 104: 30-37
        • Retnakaran R.
        Hyperglycemia in pregnancy and its implications for a woman's future risk of cardiovascular disease.
        Diabetes Res Clin Pract. 2018; https://doi.org/10.1016/j.diabres.2018.04.008